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Near-atomic resolution reconstructions of icosahedral viruses from electron cryo-microscopy

TitleNear-atomic resolution reconstructions of icosahedral viruses from electron cryo-microscopy
Publication TypeJournal Article
Year of Publication2011
AuthorsGrigorieff, N, Harrison SC
Refereed DesignationRefereed
JournalCurr Opin Struct Biol
Volume21
Pagination265-73
Date Published2011 Feb 16
Abstract

Nine different near-atomic resolution structures of icosahedral viruses, determined by electron cryo-microscopy and published between early 2008 and late 2010, fulfil predictions made 15 years ago that single-particle cryo-EM techniques could visualize molecular detail at 3-4Å resolution. This review summarizes technical developments, both in instrumentation and in computation, that have led to the new structures, which advance our understanding of virus assembly and cell entry.

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