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Nanoscale flexibility parameters of Alzheimer amyloid fibrils determined by electron cryo-microscopy

TitleNanoscale flexibility parameters of Alzheimer amyloid fibrils determined by electron cryo-microscopy
Publication TypeJournal Article
Year of Publication2010
AuthorsSachse, C, Grigorieff N, Fändrich M
Refereed DesignationRefereed
JournalAngew Chem Int Ed Engl
Volume49
Pagination1321 –1323
Date Published2010 Jan 12
KeywordsAlzheimers disease, amyloids, electron microscopy, nanotechnology, Protein Folding
Abstract

Versatile nanomaterial: Unusually high nanoscale flexibility was displayed by amyloid fibils in electron microscopy studies (see picture). This finding is relevant for understanding amyloid pathogenicity and for potential biotechnological applications.

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