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SIGNATURE: a single-particle selection system for molecular electron microscopy

TitleSIGNATURE: a single-particle selection system for molecular electron microscopy
Publication TypeJournal Article
Year of Publication2007
AuthorsChen, JZ, Grigorieff N
Refereed DesignationRefereed
JournalJ Struct Biol
Volume157
Pagination168-73
Date PublishedJan
ISBN Number1047-8477 (Print)
Accession Number16870473
Keywords*Algorithms, Computational Biology, Cryoelectron Microscopy/*methods, Hemocyanin/chemistry, Pattern Recognition, Automated/*methods, Spectrum Analysis/methods
Abstract

SIGNATURE is a particle selection system for molecular electron microscopy. It applies a hierarchical screening procedure to identify molecular particles in EM micrographs. The user interface of the program provides versatile functions to facilitate image data visualization, particle annotation and particle quality inspection. The system design emphasizes both functionality and usability. This software has been released to the EM community and has been successfully applied to macromolecular structural analyses.

URLhttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16870473
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