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Structure of the respiratory NADH:ubiquinone oxidoreductase (complex I)

TitleStructure of the respiratory NADH:ubiquinone oxidoreductase (complex I)
Publication TypeJournal Article
Year of Publication1999
AuthorsGrigorieff, N
Refereed DesignationRefereed
JournalCurr Opin Struct Biol
Date PublishedAug
ISBN Number0959-440X (Print)
Accession Number10449365
Keywords*Protein Conformation, Animals, Bacterial Proteins/chemistry/metabolism/ultrastructure, Binding Sites, Cattle, Iron/chemistry, Microscopy, Electron, Mitochondria/chemistry, Models, Molecular, NAD(P)H Dehydrogenase (Quinone)/*chemistry/metabolism/ultrastructure, NAD/metabolism, Sulfur/chemistry

Three-dimensional structures of NADH:ubiquinone oxidoreductase (or complex I) from the respiratory chain of mitochondria and bacteria have been recently studied by electron microscopy. The low-resolution structures all reveal a characteristic L shape for complex I; however, some of the differences among these structures may have important implications for the location of the functional elements of complex I, for example, the ubiquinone-binding site.

Grigorieff_CurrOpt1999.pdf2.53 MB