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Priyanka Abeyrathne

Priyanka Abeyrathne

ClC ChannelsThe chloride channel (ClC) family proteins function as transporting chloride ion across the membranes of prokaryotic and eukaryotic cells. Mutations in these proteins are the case of many hereditary diseases, including myotonia congenita, Dent’s disease, Bartter’s syndrome, osteoporosis, Neuronal Ceroid Lipofuscinoses and idiopathic epilepsy. The ClC family is comprised of both channels and antiporters, which are traditionally considered to be structurally distinct. Accordingly, it is important to study ClC family proteins to examine the boundary between channels and transporters, to understand how these proteins work in vivo, and to create a basis for the development of more efficient drugs to treat diseases caused by mutations in theses proteins. All the structural information on the ClC family only exists for the isolated transmembrane catalytic domains and the cytoplasmic regulatory domains. The main goal of this project is to obtain the structural information of full-length protein by electron cryo-microscopy and to address the regulatory mechanisms governed by the cytoplasmic domain.






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